This study was to seek the opinion of teachers and students on school-based factors that affect education and completion in Sekyere South District and the Asante Mampong Municipality of Ghana. The population for the study was teachers and students selected from nine circuits in these two-study areas. In all one thousand and eighty teachers and students were sampled to take part in the study. Questionnaire was used for data collection. Data was analysed descriptively using frequencies and percentages, means and standard deviation. The study revealed that school location, inadequate learning materials, lack of well-equipped school libraries were some of the factors affecting students' education and completion in these educational directorates. The study recommends that the district and municipal directorates of education and other stakeholders in education take it upon themselves to educate students on the adverse effects of truancy and reducing large class size in addition to providing learning resources. Teacher and student motivation are crucial in enhancing optimal performance and quality education. Hence, educational stakeholders in the study area should strategize to reward hard working teachers to enable them give of their best to step up performance in school and ensure school completion. It is also recommended that periodic workshops should be organized for teachers, to educate them on best practices in education today to improve education and school completion in the study area.