Changes in land use type (LUT) are a major driver of biodiversity loss and species decline. Responses to changes in LUT are species-specific, which may in turn be context-dependent.  Understanding such responses is essential for the management of socio-economically important wild tree species. The baobab, Adansonia digitata L., is an important traditional agroforestry tree species in Sub-Saharan Africa. This study assesses how LUT affects the demographic and spatial structure of baobab stands. Using data from a census and mapping of baobab trees in 12 plots of 250 m × 250 m each, the study compared baobab tree density, total height and diameter, diameter size-class distribution (SCD), stand stability, and spatial relationships in a strictly protected area (national park), a buffer zone and farmlands (Matéri and Boukombé) in the Pendjari Biosphere Reserve in Benin. The results show that the highest young and adult tree densities are in farmlands (particularly in Matéri), followed by the buffer zone and the national park. No significant differences in tree diameter and total height of baobab trees were found among the different LUT. The SCD had a reverse J-shape with a better negative slope and population stability metrics in farmlands (particularly in Matéri) but a flattened slope in the buffer zone. The spatial distributions of juvenile and adult baobab trees were random, and independent of each other. The spatial distribution of juvenile and adult baobabs was also independent of the other tree species, irrespective of LUT. It was concluded that baobab conservation is better in farmlands than in the national park but that the difference between park and farmlands may be context-dependent, probably linked to local environmental conditions, the socio-ecological context and interactions with baobab trees.