Nowadays, energy consumption in buildings is one of the fundamental drivers to control greenhouse gas emissions and environmental impact. In fact, the air quality of urban environments can cause two main phenomena in metropolitan areas: urban heat island and climate changes. The aim of this work is to showcase how different building variables can impact the residential building’s space heating and cooling energy consumption. Buildings energy-related variables can be fundamental viewpoints to improve the energy performance of neighborhoods, especially in future urban planning. This work examines four neighborhoods in the city of Turin (IT): Arquata, Crocetta, Sacchi, and Olympic Village characterized by different morphologies and building typologies. In each neighborhood, residential building was grouped according to orientations and construction periods. A sensitivity analysis was applied by analysing six building variables: infiltration rate, window-to-wall ratio, and windows, walls, roofs, and floor thermal transmittances. The energy consumption for space heating and cooling of residential buildings and local climate conditions were investigated using CitySim Pro tool and ENVI-met. The challenge of this work is to identify the building variables that most influence energy consumption and to understand how to promote high-energy efficiency neighborhoods: the goal is to identify the “ideal” urban form with low consumption and good comfort conditions in outdoor urban environments. The results of this work show a significant connection between the energy consumption and the six analyzed building variables; however, this relationship also depends on the shape and orientation of the neighborhood.