The CD6 scavenger receptor is known to be expressed on virtually all T cells and is supposed to be involved in costimulation, synapse formation, thymic selection and leukocyte migration. Here, we demonstrate that CD6 is differentially expressed by a subpopulation of peripheral CD56^dim natu- ral killer (NK) cells and absent on CD56^bright NK cells. CD56^dimCD16⁺ cells represent the major NK subset in the periphery, and most cells within this group are positive for CD6. Most killer immunoglobulin-like receptor- and immunoglobulin-like transcript-positive cells also belong to the CD6⁺ subpopulation, as expected from their restricted expression on CD56^dim NK cells. In addition, CD6⁺ NK cells are similar to the newly identified CD94^lowCD56^dim NK subpopulation and most distant from the recently defined CD27⁺ NK subpopulation based on the reverse correlation of expression between CD6 and CD27, a marker associated primarily with CD56^bright NK cells. With respect to CD6 function on NK cells, direct CD6 triggering did not result in degranulation but induced secretion of cytokines (interferon-γ and tumor necrosis factor-α) and chemokines [CXCL10 (IP-10), CXCL1 (GRO-α)]. Thus, CD6 expression on peripheral NK cells marks a novel CD56^dim subpopulation associated with distinct patterns of cytokine and chemokine secretion.

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Résumé -Caractéristiques de personnalité et d'identité dans les enquêtes -Approches pour l'opérationnalisation et la localisation de variables pour expliquer le sentiment de bien être : Les caractéristiques de personnalité et d'identité ne sont pas habituellement comprises dans des études sociologiques. De telles questions sont considérées de faire partie de la psychologie. Mais la sociologie peut développer des outils de recherche pour les opérationnaliser d'une manière efficace et succincte. Cet article, basé sur une enquête représentative de la population autrichienne, montre que: (1) il est possible de saisir de telles caractéristiques avec des outils relativement simples, et (2) les caractéristiques de personnalité et d'identité peuvent expliquer une partie importante de la variance dans le sentiment de bien être. Des échelles spécifiques ont & e a c u t e ; t & e a c u t e ; développées pour saisir les « Cinq grands & r a q u o ; ("Big Five") facteurs de la personnalité, quatre aspects du soi et onze aspects de l'identité sociale. Cinq grands (Big Five), Traits de la personnalité, Enquêtes représentatives, Bien être.Abstract: Characteristics of identity and personality are usually not included in sociological studies. Questions of this sort are considered as belonging to the domain of psychology. However, sociology can also develop research instruments to operationalise them in a short and efficient way. This article, based on a représentative Austrian population survey, shows that (1) it is possible to grasp such characteristics with relatively simple instruments, and (2) characteristics of personality and identity can explain a considerable amount of the variance in life satisfaction. Specific scales were developed and used to capture the "Big Five" personality factors, as well as four aspects of the self and eleven aspects of social identity. Big Five, Personnality Traits, Representative Surveys, Life Satisfaction.