This study dealt with response to land degradation in Muduuma Sub-County, Mpigi District-Uganda. The study employed the cross sectional design due to its ability to collect data on more than one case from different respondents and at a single point in order to receive a body of quantitative data in connection with two or more variables. The target population was all the 9121 farmers of Muduuma Sub- County. However, only 114 of the total population was purposively sampled basing on the researcher’s judgment that only arable farmers were fit for the study. Data was collected through a questionnaire, an interview guide and a Focus Group Discussion Guide and it was analyzed through the descriptive statistics and the thematic approach. The study concludes that the majority of farmers had knowledge of land degradation. This was shown through the various actions taken to address the phenomenon despite having limited formal education. Methods used include organic manure, mulching, trenching, afforestation and fertilizers. Therefore, knowledge about causes and impact of land degradation to households is required. Once the population is more informed about the dangers of land degradation, it is easier to develop suitable soil management practices which in turn promote appropriate resource management practices for sustainable economic growth and development.