The uncommon complications regarding CKD tend to increase in clinical setting because of the chronic kidney disease (CKD) population has been expanding every passing day. Perhaps the most important one of these is calcific uremic arteriolopathy (CUA, calciphylaxis). Calcific uremic arteriolopathy is a clinical syndrome which includes systemic calcification of the small vessels, causes to ischemia, subcutaneous necrosis and it has high mortality and morbidity rates (1,2). There is a large body of data in literature about CUA although very little for its cardiac involvement. Herein we presented a case of calcific endocarditis with CUA and the review of the literature. According to our observation, parathyroidectomy was effective to provide clinical and radiological improvement in the presented case. The clinician should consider adding parathyroidectomy to conventional strategies immediately if the risk of such uncontrolled hyperparathyroidism is present.