Venous ulcers are a frequently encountered problem in the present era produced commonly as a complication of varicose veins and it causes long-term agony to the patient. The properties of a venous ulcer-like non-healing na- ture, severe discharge pain itching etc. come under the umbrella of Dushtavrana explained by Acharya Sushruta. Management of chronic venous ulcers is a challenging one. Commonly practised gauze dressing for chronic ulcers may be disruptive for wound healing as it gets adhered to wound bed hampering breathing of wound and causing damage to granulation tissue during its removal. These factors may be responsible for delayed wound healing. In modern science, there are plenty of sterilized, packed dressing materials available in the market. But nowhere Ayurvedic ready to use dressing material is manufactured or made available in the market. Keeping these into con- sideration, Jatyadi Ghrita Vikeshika i.e., the cloth containing Jatyadi Ghrita is prepared, packed and sterilized. This is compared with the Sofra-tulle of modern science. In the present comparative study, 40 patients were select- ed and divided into 2 groups of 20 patients each and trial group patients were treated with Jathyadi Ghrita Vike- shika dressing & control group patients were treated with Sofra-tulle dressing for 28 days. The study revealed highly significant results in both groups statistically. On observation except for pain, in all other parameters, Jatyadi Ghrita Vikeshika was found more effective. Hence Jatyadi Ghrita Vikeshika can be undoubtedly used in Dushtavrana which promotes both Shodhana (Cleansing) and Ropana (Healing)of Vrana. Keywords: Dushtavrana, Venous Ulcer, Jatyadi Ghrita Vikeshika, Sofra-Tulle dressing.

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