Eccrine syringofibroadenomas is typically a benign rare neoplasm. Eccrine syringofibroadenomas (ESFA) originates from or is differentiating toward the acrosyringium or eccrine dermal duct. Histologically, there are multiple anastomosing cords of benign epithelial cells surrounded by a loose fibrovascular stroma. The epithelial cords demonstrate ductal differentiation. Occasional luminal eccrine ducts are noted within the anastomosing cords. The authors describe two cases with different subtypes of ESFA, a solitary ESFA and a reactive ESFA with squamous cell carcinoma.

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