In this review, works of various researchers working on the synthesis of indazole and their related compound are cited. The review comprises of methodologies for the synthesis of 1H and 2H indazole derivatives, along with some pharmacological activities. In this review, research papers published in various peer-reviewed journals between the year 2000 and year 2017 are enlisted in alphabetical order.

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Background: An eco-friendly, operationally simple and efficient reaction is shown between various 2,6-bis- (substituted-benzylidene)-cyclohexanone and different substituted hydrazine in presence of acetic acid. Methods: The reaction between various 2,6-bis-(substituted-benzylidene)-cyclohexanone and different substituted hydrazine in presence of acetic acid afford 7-Benzylidene-substituted-phenyl3,3a,4,5,6,7-hexahydro-2H-indazole in 74 to 92 % yield in short reaction time using grindstone technique. Results: Mild synthetic conditions, weak acid catalysis, non-hazardous solvent and environmentally safe are notable advantages of this method Conclusion: In conclusion, we have developed an efficient, simple and eco-friendly method for synthesis of 7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7-hexahydro-2H-indazole by grinding technique. The notable benefits of this method are waste minimization, no organic solvent required, simple procedure, easy work-up, clean reaction profile.

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