The present review is based mainly on papers published between 2000 and 2011 and gives information about the properties of the carotenoid lycopene in chemical and biological systems and its possible role in preventing cardiovascular diseases (CVD). The main aim of this report is to highlight its role as an antioxidant, also reported are bioactive properties that may influence the development of foam cells and protection against endothelial cell damage. The paper will also examine recent observations that lycopene may improve blood flow and reduce inflammatory responses. Lycopene possesses antioxidant properties in vitro, and some epidemiological studies have reported protective effects against the progression of CVD. The oxidation of human low density lipoproteins (LDL) is a fundamental mechanism in the initiation of atherosclerosis. A beneficial role of lycopene as antioxidant in the prevention of CVD is suggested but the data are still controversial. Lycopene is believed to be the most potent carotenoid antioxidant in vitro. Tissue culture experiments and animal studies support potential cardioprotective effects for lycopene and other carotenoids in the blood. Most studies showed beneficial effects of lycopene to individuals who are antioxidant-deficient like elderly patients, or humans exposed to higher levels of oxidative stress like smokers, diabetics, hemodialysis patients and acute myocardial infarction patients. By defining the right population and combining antioxidant potentials of lycopene with vitamins and other bioactive plant compounds, the beneficial role of lycopene in CVD can be clarified in future studies. Keywords: Atherosclerosis, isomerization, in vitro, in vivo, LDL oxidatin

The present review is based mainly on papers published between 2000 and 2020 and gives information about the properties of the Chondroitin sulphate, Collagen and rosehip Extract in chemical and biological systems and its possible role in preventing Musculoskeletal system diseases. The main aim of this report is to highlight their role and therapeutic applications in the Musculoskeletal system, also reported are their bioactive properties which may influence the development of treatments and protection against Musculoskeletal system cell damage. The paper will also examine recent observations in various fields

Bioactive peptides are protein parts which positively affect the capacities and states of living creatures. Peptides have demonstrated a few helpful properties for human wellbeing, including antimicrobial, antifungal, antiviral, and antitumor exercises. These mixes are delivered by practically all types of life. Notwithstanding, they are delivered in restricted amounts in nature. Subsequently, scientists have attempted to integrate bioactive peptides to contemplate their properties and applications in different zones. This review delivers a concise portrayal of the applications utilized by peptides: Triptorelin Acetate, Thymosin Alpha 1, Leuprolide acetate, Liraglutide, Desmopressin Acetate, Teduglutide, Pramlintide, Oxytocin, Calcitonin, Octreotide and Triptorelin. Keywords: Triptorelin Acetate, Thymosin Alpha 1, Leuprolide acetate

The present review is based mainly on papers published between 2000 and 2020 and gives information about the properties of the Folic Acid and Beta Carotene in chemical and biological systems and its possible role in preventing several diseases. The main aim of this report is to highlight its role as an immunopathological applications, also reported are bioactive properties that may influence the development of foam cells and protection against endothelial cell damage.

Melanoma skin cancer is a primary cutaneous malignancy. Melanoma cancer of the skin cell is one of the major skin cancer worldwide, ranking first in frequency. Melanoma skin cancer has been strongly associated with psoriasis. Here, we use computational methods in an effort to identify possible biomarkers for psoriasis related Melanoma skin cancer. To do this, we downloaded gene expression microarray data from the GEO (Gene Expression Omnibus) database in the GSE series: GSE14905 and pre-processed it in the Bioconductor repository for R. The data was screened for DEGs using a rigorous methodology, which included the use of statistical testing methodologies and tools (Differentially Expressed Genes). Psoriasis has 6749 up-regulated genes and 7142 down-regulated genes. Psoriasis DEGs were combined with the NCG dataset resulting 874 up-regulated genes and 74 down-regulated genes for an in depth analysis of how differential expression can lead to malignancy. we used stringDB diseases dataset in Cytoscape to generate network of melanoma proteins, which were further mapped to DEGs and igraph to construct a GRN. In addition, module level analysis was carried out because of the benefits it provides in terms of stability and comprehension of intricate GRNs, resulting 17 biomarkers (17 up-regulated). There is an emphasis on the network's topology as well. The findings suggest that the network has a hierarchical structure. Additionally, survival analysis of 8 biomarkers results obtained from intersection mapping of skin cancer stringDB and biomarkers, was carried out. Significant enrichment of KEGG pathways was found. They also illuminate the interplay between biomarkers whose upregulation may lead to melanoma skin cancer. These findings may inform future investigations and the identification of potential therapeutic targets for this condition as well as shows the potential link between psoriasis and melanoma.