Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of SJS is seen in five cases per million people per year. SJS is typically caused by drugs and is a kind of idiosyncratic reaction. Adverse drug reactions such an SJS have a remarkable effect on patient's safety issues. We encountered nine cases of antiepileptic drug (AED)-induced SJS, specifically with carbamazepine, oxcarbazepine, and phenytoin. To manage the reaction, the clinician withdrew the drug in all 8 cases, and in 1 case, the patient was shifted to valproate and symptomatic treatment was provided. There is still a controversy whether or not all AEDs can cause SJS. Recent studies have investigated the role of genetic factors - HLAB*502 allele in the development of AED-induced SJS in patients of Asian ancestry.

UNSTRUCTURED From March to June in 2020, most of the world underwent social isolation, mandated quarantine, or lockdown to prevent the excessive spread and eventual casualties from COVID-19. Such isolation meant a dramatic change from routine livelihood. Though the isolation was essential to contain the disease spread, we argue that the drastic change from daily life must have led to several psychological issues. There is a lack of enough evidence and research in the literature about the mental health of the Indian population. This also leads to a lack of awareness of symptoms and presentations of different disorders of mental health in the general public. Therefore, we chose this target population to help us recognize the culture-specific and general effects of lockdown and social isolation on their psyche. The present study has both qualitative and quantitative arms. The qualitative arms of this study aim to analyze the psychosocial and behavioral effects of social isolation and mandated quarantine or lockdown, along with assessing the amount of awareness and knowledge regarding the disease spectrum caused by COVID-19 in the Indian population. The quantitative arm of the study aims to examine the extent of association between psychosocial/behavioral effects and various demographic factors in the said target population, viz. age, sex, etc. The main purpose of the study is to establish the present status of mental health in the general Indian population and the direct effects of social isolation due to the COVID-19 pandemic.

No abstract

Background: The purpose of the study was to study awareness and knowledge amongst girls about breast self-examination and breast cancer.Methods: An educational interventional study was carried out among 150 students of V. S. Hospital, School of Nursing. Students were educated about prevalence and severity of breast cancer as well as early detection techniques in an interactive lecture. Pre- and post-tests were administered before and after session. Data was analysed by using Epi Info 3.5.3.Results: It was found that 91% subjects were aware of the term of breast self-examination (BSE). Post intervention, awareness increased by 100%. Half of the subjects believed that practice of breast self-examination should begin at the age of 20 years, poste intervention, awareness increased in 93%. Approximately one fourth of the students were aware of the ideal frequency of performing BSE, after the intervention, awareness level increased to 83%. Only 27% of subjects were aware of technique of BSE. Post the intervention, it was found that 87% became aware about the correct technique. There was improvement of 49% in knowledge about indicators of breast cancer.Conclusions: There was increase in awareness among girls about breast self-examination and breast cancer after intervention.

Background During the year 2020, the COVID-19 pandemic spread from China to the rest of the world, which prompted the world to implement a widespread mandated quarantine or social isolation. The impending uncertainty of the pandemic must have resulted in a variety of widespread mental health maladies. There has been documentation in the literature about a lot of these in small populations of the world but limited studies have been conducted in India, leading to limited evidence in the literature. Objective The main objective of our study is to investigate the mental health effects that the COVID-19 pandemic has had on the general population in India both quantitatively and qualitatively. These results will help contribute to reducing the knowledge gap that is recognized in the literature, which is the result of the unprecedented and novel nature of the pandemic. Methods We designed and validated our own questionnaire and used the method of circulating the questionnaire via WhatsApp (Facebook Inc). WhatsApp is a social media app that is very popularly used in India; hence, it turned out to be an effective medium for gathering pilot data. We analyzed the pilot data and used them to validate the questionnaire. This was done with the expertise of our mentor, Nilima Shah, MD (psychiatry). We gathered pilot data on 545 subjects and used the results to determine the changes that were needed for the questionnaire while simultaneously validating the questionnaire. Results The study protocol was approved in September 2020 by the institutional review board at Vadilal Sarabhai General Hospital, Ahmedabad, Gujarat, India. Conclusions The following preliminary assumptions can be made about the study based on the pilot data: the majority of the survey respondents were male (289/545, 53%), most of them were educated and employed as health care workers (199/545, 36.5%). The majority of the responders were self-employed (185/545, 33.9%), single (297/545, 54.5%), and stayed with their families (427/541, 79%) for the lockdown, which helped them psychologically. Findings that are specific to mental health have been elaborated upon in the manuscript. It is evident from the data collected in previous literature that the pandemic has had significant detrimental effects on the mental health of a vast proportion of the Indian population. International Registered Report Identifier (IRRID) DERR1-10.2196/29896