Article InfoIn this study, field experiment was conducted to assess the effect of different doses of NPK on tuber yield on the potato (Solanum tuberosum L.) varieties such as Inovator, Gala, Aladin and Tyanshansky in foothill zone of the southeast of Kazakhstan. Five different combinations of NPK with control were studied. Results revealed that the fertilizer application increased the total tuber yield, the longest plant, number of main stem, number of leaves plant and average tuber number on the potato significantly over control. The highest tuber yield was obtained when 25% more than the recommended fertilizer dose with manure was applied at all potato varieties. Aladin potato variety significantly yielded higher than the other varieties tested at the same time in this experiment.