The active moiety with poor solubility is posing a challenge in drug development which may reduce the effectiveness in patients when administered orally. Cocrystal formation is one of the latest approaches for improving the various parameters of a drug molecule such as solubility, melting point, pharmacokinetic, pharmacodynamic, and bioavailability. Cocrystals are crystalline single state materials composed of two or more than two different molecular amalgams held together in a fixed stoichiometric ratio. There are various techniques used for the preparation of cocrystals such as solvent evaporation, grinding, and cooling crystallization. The quantitative and qualitative aspects of these cocrystals are evaluated using various validated instruments such as nuclear magnetic resonance, powder X-ray diffraction, and differential scanning calorimetry.

Allicin (Allium sativum) the most commonly used food constituents is when chopped or crushed release allin in the presence of enzymes Allinase, by losing one molecule of water and forms an active chemical constituent, Allicin. It acts as ACE inhibitor by relaxing the endothelial cells of the heart through release of nitrous oxide formation and finally decreases the peripheral resistance of heart result antihypertensive effect. It also reduces the oxidative stress level in hypertensive rats which also proves that it has as anti-hypertensive activity. It has various other mechanisms that reduces hypertension in humans.

Kikuchi-Fujimoto Disease (KFD) is also known as Histiocytic Necrotizing Lymphadenitis. It is very rare, noncancerous and self-limiting Auto-Immune disease but mostly suspected as cancer, tuberculosis and systemic lupus erythematosus. It has symptoms such as cervical lymphadenopathy (enlargement of lymph nodes), low fever, headache, fatigue, night sweats and muscles pain. It typically affects young females aged between 20-35 years and mostly affects Asian populations. The main identification of KFD is characterized by Fine Needle Aspiration Cytology by taking blood sample from the swollen lymph node. Diagnosis is also possible with Fine Needle Aspiration Biopsy. Treatment for this disease has not been established. Non-steroidal Anti-Inflammatory Drugs or steroids are in use to ease the tenderness of lymph node and fever.