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Population density and seed tuber is an important agronomic management practices in the production of potato (Solanum tuberosum L.). However, potato farmers in Ethiopia often use random population density and tuber sizes, which contribute to the low yield of the crop. Thus the objective of this study is to review effect of population density and tuber size on yield components and yield of potato. The result of this review shows that the highest plant height and main stems number was found in wider spacing and in medium to large tuber size. In the same way, the number of tuber per plant, average tuber weight and marketable yield increased when potatoes are planted in medium intra row spacing (60 x 30) and using medium (35 to 45 cm) to large (45 to 55 cm) tuber size. However, total tuber number/ha and unmarketable yield increased in closer spacing and medium (35 to 45 cm) tuber size. Thus according to the review to increase total yield and marketable yield, it is better to use medium plant spacing (60 x 30 cm) and medium-sized tubers (35 to 45 mm).