Objectives: To correlate the clinically diagnosed prostatic lesion with histopathological evaluation, Gleason scoring andserum prostate specific antigen (PSA) levels in a tertiary care centre. Study Design: Observational Study. Setting: The current study was conducted in multiple centers of Sindh like Department of Surgery Unit-III, Peoples University of Medical and Health Sciences, Nawabshah CMCH Larkana, Jinnah Sindh Medical University and Al-Tibri Medical College and Hospital Karachi. Period: January 2018 to December 2019. Material & Methods: on 112 consecutive cases of clinically diagnosed prostatic disease, all the relevant demographic and clinical details including digital rectal examination (DRE) findings and serum PSA levels were recorded on a proforma designed for the study. PSA values of all these cases were recorded before the surgical procedure. The tissue sample of prostate was collected after surgery and histologically analysed for the confirmation of diagnosis and the Gleason scoring was made. All the results obtained were statistically analysed and tabulated. Results: The age of patients ranged 34-81 years, with mean age of 58+3.4 years. The adenocarcinoma was detected in 05 cases, hyperplasia in 92 cases and hyperplasia with prostatitis in 07 cases. The carcinoma was clinically diagnosed in 17 cases but after histological evaluation, the carcinoma was confirmed in 03 cases and 02 cases of cancer were confirmed among clinically diagnosed cases of hyperplasia. Majority of cases of hyperplasia were having the PSA level < 4ng/ml No any case of adenocarcinoma have PSA level below 4ng/ml, and majority of the cases of denocarcinoma were having PSA level above 20ng/ml. majority of malignant lesions were having PSA level above 20ng/ml and the Gleason score above 6. No any case of malignancy was detected in those patients having PSA level below 4ng/ml. Conclusion: The histopathological evaluation with serum PSA levels is necessary in all cases of prostatic disease to rule out the possibility of malignant pathology.

Objectives: To determine the outcome of extracorporporeal shock waves lithotripsy for high density renal stone on non-contrast computed tomography. Study Design: Descriptive study. Setting: Urology Department of Sindh Institute of Urology and Transplantation, Karachi. Period: 1st November 2017 to 31st October 2018. Material & Method: Patients in the age range of 25-75 years were selected, irrespective of their gender. After 12 weeks final outcome of ESWL was measured by performing plain X-ray KUB films before and after procedure. Satisfactory outcome was defined as stone clearance in <3 sessions of the procedure. Results: According to our inclusion and exclusion criteria 122 patients were selected for ESWL. Among them there were 41.8 (n=51) females and 58.1% (n=71) males. The mean age of the patients was found to be 34.08+ 9.53 years. Approximately more than half of the patients 57.4% (n=70) patients were present in the age group of in ≤35 years. The mean size of the stone was 1.51+ 0.5 cm whereas mean stone density as scan was 772 + 22.2HU. Patients were having renal or ureteric stones for mean duration of 2.07 + 0.31 months. Around 69.7% of patients had renal stones and 30.3% of patients had ureteric stones. Stone clearance was found in 58.2% (n=71) of the patients. Conclusion: Non-contrast enhanced CT scan is the most frequently used investigation to diagnose kidney stones and decide its treatment modality. Outcome of ESWL also depends on various factors as mentioned in the study.

Introduction: Urinary Bladder stone can result in variety of lower urinary tract symptoms. Bladder stone is common in extreme of ages i.e. pediatric population and geriatic population. Overall prevelance of the disease is not that high. With increase in health care facilities and screening investigations like ultrasound, this condition is easily diagnosed. Traditionally just like renal or ureteric stones open cystolithotomy was the treatment of choice but with advancement in endourological instruments and miniturization it is now frequently dealt by minimally invasive techniques like percutaneous cystolithotomy. The aim of our study was to compare the results of urinary bladder stone surgical managements. Methods: After ERC approval we conducted this descriptive retrospective study. For data collection record of pediatric patients admitted in Urology Unit, Khyber Teaching Hospital Peshawar Pakistan during the period from April 2022 to January 2023 was used. 110 pediatric patients with urinary bladder (UB) stones who underwent surgery were enrolled in our study. According to type of intervention, patients were stratified into two groups, (Group O) underwent open cystolithotomy, and (Group P) underwent endo-urological treatment via the percutaneous route.60 patients underwent open cystolithotomy (OCL), while 50 patients  underwent percutaneous cystolithotomy (PCCL).

Introduction: Hypospadias is a congenital defect with various presentations. It is diagnosed clinically. Hormonal therapy can be used but is not curative. The Snodgrass intervention is the better one to get result oriented outcomes. Objectives: To find out the advantages of Snodgrass repair in distal as well as proximal types of hypospadias. Study Design: Cross sectional study. Setting: Baqai university hospital Karachi. Period: January 2015 to December 2017. Material and Method: Total 40 male patients were included in this study. They were admitted through OPD. Age of patients was from 4 years to 22 years. Patients were prepared and Snodgrass repair was done to all patients. Results: In our study, of 40, 19 (47.5%) patients presented between age 04 to 10 years. Most common Subcoronal type was found in 16 (40%). Catheter blockage was in 4 (10%) patients that was a common complication in our study. Conclusion: To sum up, Snodgrass method is the good one with good cosmetic results and least complication rate.

The aim of this study is to determine the frequency and risk factors for hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (Anti-HCV) in a preoperative screening of patients admitted at the surgical unit of Al