Background: Occupational workers especially those working in industries associated with metal and mining activities are excessively exposed to many toxic metals, which affect them. This study was conducted to determine the metal concentrations in body fluids of blacksmiths exposed to metals. Methods: The present study was conducted on a total of 140 male blacksmiths and 120 male controls in Kano Metropolis, Nigeria. All information related to working conditions such as duration of engagement and use of personal protective equipment (PPE), health history, life style, etc. were obtained using an interview questionnaire. Blood samples were also collected, digested, and subsequently, subjected to flame atomic absorption spectrometric (FAAS) analysis to determine the heavy metals concentration in the samples. Results: Exposure to heavy metals led to various degrees of health complications including headache (68%), fever (52%), chest pain (44%), itching (43%), irritation (35%), shortness of breath (31%), and coughing (27%). Meanwhile, the concentration of blood heavy metals of Pb, Cd, Cr, and Zn was 0.17, 0.076, 0.24, 4.50 µg/mL, respectively. The values were above the permissible limits of the American Conference of Governmental Industrial Hygienists (ACGIH) and significantly differ from those in controls (P<0.05), which was directly proportional to age and exposure rates. Conclusion: According to the results, blacksmithing is an occupation with health hazards, which affect blood metals levels, and subsequently, lead to serious health complications.