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Biomimetic internal architecture is proving valuable for multi-tissue and structural tissue interface engineering. A biomimetic method developed for the in situ synthesis of hydroxyapatite in poly (vinyl) alcohol, produces nanocomposites in the form of fabric-like sheets, when subjected to lyophilisation. The surface reactive hydroxyl groups of poly (vinyl) alcohol encourage site-specific coupling of hydroxyapatite. This results in improved mechanical properties, which may be better for biomedical applications when compared to a mere blend of the above two.

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