The Schmidt reaction, the treatment with hydroazoic acid in the presence of a strong acid, converts ketones to amides directly and has been broadly applied in organic synthesis. In this communication, the Schmidt reaction of ketones was carried out in DME solution in a continuous-flow microreactor and gave the amide products. The enclosed small-volume feature of the microreactor made this reaction safe, fast, and costeffective.

HNMR spectra 13 C-NMR spectra were recorded on JEOL ECA NMR spectrometer (1 H 400 MHz, 13 C 100 MHz). HPLC analysis was performed on Agilent 1200 (DAD: 254 nm, column: agilent zorbax eclipse XDB-C18 (4.6×150 mm, I.D. 5 µm)). ESI mass spectra were recorded on Bruker micrOTOF II. All reagents were obtained from