No abstract

ABSTRACT.Purpose: Photodynamic therapy utilising d-aminolevulinic acid-induced protoporphyrin IX photosensitisation, was evaluated as a treatment modality for nonmelanoma skin malignancies of the eyelids and the periocular skin.

No abstract

ABSTRACT.Purpose: Investigation of the full-field ERG (electoretinography) within 24 hours after the onset of symptoms in central retinal vein occlusion, and repeated examination within the following days and weeks. Methods: Seven patients with central retinal vein occlusion were examined with full-field ERG within less than 24 hours after the onset of their symptoms and every second to third day during the first 3 weeks. They were then followed for a period of time of six months. Results: The amplitudes as well as the implicit times in the 30 Hz flicker ERG changed considerably within the first three weeks. In the three patients who developed rubeosis, the cone b-wave implicit times as well as the amplitudes were altered considerably. In the patients that did not develop rubeosis, the cone b-wave implicit times as well as the amplitudes in the 30 Hz flicker ERG were more stable. , and have to be treated with panretinal photocoagulation (Laatikainen et al. 1976; The Central Vein Occlusion Study Group N Report 1995;Magargal et al. 1982). The non-ischemic central retinal vein occlusion does not develop rubeosis, and the outcome of the visual acuity is fairly good. Early in the disease it is usually very difficult to predict which eyes are going to develop rubeosis and which ones are not.Previous investigations have shown that the ERG has a good predictive value for rubeosis in central retinal vein occlusion. In these studies patients with a few days up to many months duration of their central retinal vein occlusion have been examined (Vannas 1960;Sabates et al. 1983;Kaye & Harding 1988;Severns & Johnson 1993;Johnson et al. 1988;Johnson & McPhee 1993;Hayreh et al. 1989Hayreh et al. , 1990Karpe 1945;Morrell et al. 1991;Breton et al. 1989;Williamson et al. 1997;Larsson et al. 1998). We have earlier reported on a group of patients with central retinal vein occlusion, who had their first ERG examination done within 2 weeks after the onset of their symptoms. In this investigation, the 30 Hz flicker ERG had the best predictive value for rubeosis (Larsson et al. 1998) early in the disease.The purpose of our study was to investigate the ERG parameters very early in the course of central retinal vein occlusion, less than 24 hours after the onset of symptoms, and how these parameters changed within the following days and weeks. We also wanted to find the optimal time to perform a predictive ERG examination. Patients and MethodsPatients 7 patients, 3 women and 4 men, with an acute central retinal vein occlusion were recruited from the eye clinics of the Lund University Hospital and from the Medical Center Hospital in Helsingborg. The average patient age was 66 years (range 59-75 years). In the rubeotic group the average age was 70 years (range 69-74 years) and in the non-rubeotic group 68 years (range 59-75 years).At the time of their first ERG examination the patients had had symptoms central retinal vein occlusion between 10-23 hours. Only patients that could very distinctly tell at what time they noticed deterioration of...

ABSTRACT.Background: Central retinal vein occlusion is a disease that is most common in old people, and often associated with atherosclerosis, hypertension, diabetes or glaucoma. Since these diseases are much less evident in young people, we wanted to investigate the prevalence of disorders in the most common anticoagulant proteins in a group of young patients with central retinal vein occlusion. Methods. 37 consecutive patients younger than 50 years and with a history of central retinal vein occlusion, were analysed for deficiencies of natural inhibitors of coagulation (protein C, S, and antithrombin III), plasminogen, resistance to activated protein C, and the presence of anticardiolipin or lupus anticoagulants. Results. Anticoagulant protein deficiencies were found in 4 patients (11%) and activated protein C resistance in 7 patients (19%). Anticardiolipin or lupus anticoagulants were not found in the patients. Conclusion: Activated protein C resistance and anticoagulant protein deficiencies seem to be important factors to the etiology to central retinal vein occlusion in young patients.