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Sexually Transmitted Diseases (STD) shows various trends in different parts of the country and constitute a major public health problem for both developing and developed countries. STD`s increases the risk of transmission of Human Immuno Deficiency virus (HIV) infection causing immense need to understand the patterns of STD`s prevailing in the regions of a country for proper planning and implementation of STD control strategies. To know the pattern of STDs and to analyze the changes during a 7 year period among patients attending the STD clinic at the tertiary care centre. A retrospective analysis of data collected from the clinical records of patients attending the STD clinic of a tertiary care hospital, Mysuru over a period of 7 years (from Jan 2010 to Dec 2016). During this 7 years period, a total of 1,98,991 patients attended Skin and STD Department on out-patient basis, among them 2,111(1.06%) were STD patients [1057 males and 1054 females]. Majority were married (89.86%). The most common STD in males was balanoposthitis (32.92%) and in females was vaginal /cervical discharge (28.42%). Among genital ulcer diseases herpes genitalis was most common and increased gradually while Syphillis and Chancroid declined during the study period. Gonococcal urethritis was seen among 4.69% and LGV only in 0.14% (3 cases). HIV seropositivity in the study population was 7.25%.Bacterial STD`s showed a gradual reduction in number while fungal and viral STD`s showed increasing trends.