2205 duplex (austenitic-ferritic) stainless steel has a good weldability and an excellent corrosion resistance. The good weldability is achieved when in close to 50-50 ferrite-austenite ratio. In this study, the welding process and properties were investigated by pulsed Nd:YAG laser welding. Tensile test, surface microhardness test, surface topography and microstructures of 2205 duplex stainless steel welds were performed under different welding speeds, input currents, pulse widths, frequencies and defocus distance. The relationship among them was revealed and the optimal welding parameters were obtained. The results showed in the condition of I = 160 A, T = 5 ms, f = 25 Hz, V = 500 mm/min and Z =-1 mm, the amount of ferrite and austenite in welds was roughly same, overlap rate of solder joints was above 78% and the weldability was good.