Angelman syndrome is characterized by a partial deficit of paired autosomal chromosome 15, which contains a subunit of the GABA (Gamma-Amino Butyric Acid) receptor. Many drugs that act on the CNS (Central Nerve System) during anesthesia are believed to exert their effects via the GABA receptors. We describe the anesthesia of a 7 year-old female patient with Angelman syndrome who underwent surgery for dental caries. The basic factors that needed to be considered when administering anesthesia to this patient were epilepsy, significant dominance of the vagal tone, craniofacial abnormalities and peripheral muscular atrophy. Inhalational anesthetics (sevoflurane) were employed for this patient. The patient had an uneventful peri-operative period and was discharged home on the same day of the operation.

In order to ensure long lifetime and stable light output of LEDs the thermal performance parameters need to be designed in the LED chip package and module level, which include such items as heat sink structure and materials, interface materials and substrates. In this work we used aluminium nitride(AlN) as submount of LED chips and made chip on board(COB) type LED module. The effect of different silver(Ag) epoxy bonding materials and bonding methods on the performance of LED module were examined. The effect of addition of red quantum dot(QD) on the performance of white LED was also studied.