A novel highly diastereoselective palladium-catalyzed dearomative reaction of N-halobenzoyl o-haloaniline derivatives has been developed using functionalized N-tosylhydrazones as the coupling partners. This cascade dearomative protocol, which proceeds through a sequential...

Scheme 2. Plausible mechanism of the formation of 2 a (Ref 21). Scheme 3. Pd-catalyzed dearomative arylcyanation of indoles (Ref 22).Scheme 4. Derivatization of products (Ref 22). Scheme 5. Pd-catalyzed oxidative Heck dearomative reaction (Ref 23). Scheme 6. Plausible mechanism of the generation of 11 b (Ref 23).

Fluorinated organic compounds stand as an important class of organic molecules and play a key role in both academic and industrial communities due to the unique nature of fluorine. Among...