This paper presents the findings of a study on the factors that affect SMMEs ability to adopt E-commerce conducted in the Eastern Cape Province in South Africa. The study employed both quantitative and qualitative methods of data collection and analysis in order to ensure reliability and generalisability of the results. Qualitative data was first subjected to thematic analysis and content analysis to turn it to enumerative data. Eventually all the quantitative data was coded into SPSS for graphs and descriptive statistics. According to the findings the most significant e-business adoption variables in the province are security, prestige, government support, vision and the need to service niche markets.