No abstract

These results suggested that the Treg-Th1-Th17-Th22 cells involved in xenotransplant rejection and imbalance between Tregs and Th1-Th17-Th22 cells contribute to the acute rejection of peripheral nerve xenotransplant.

No abstract

The inoculation of vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is undergoing worldwide. However, the emergence of SARS-CoV-2 variants could confer immune evasion. Here we develop a bivalent nanoparticle vaccine, which displays the RBDs of both D614G and B.1.351 strains. With a prime-boost or a single-dose strategy, this vaccine elicits a robust neutralizing antibody and full protection against the infection of authentic D614G or B.1.351 strains in the human angiotensin-converting enzyme 2 transgene mice. Interestingly, after 8 months since the D614G-specific vaccine inoculated, a new boost with this bivalent vaccine potently elicits cross-neutralizing antibodies for SARS-CoV-2 variants in rhesus macaques. We suggest that the D614G/B.1.351-bivalent vaccine could be used as an initial single-dose or a sequential enforcement-dose to prevent SARS-CoV-2 and its variants.