Background: In recent times, single-sitting root canal therapy has gained momentum over multiple-sitting root canal therapy due to its superior clinical outcome and less time required for treating the patient. Aim: Thus, the aim of current study was to compare the expression of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) in the serum of patients undergoing single-sitting and multiple-sitting root canal treatment. Materials and Methods: This cross-sectional experimental study was conducted on 300 subjects who were indicated for root canal treatment. Subjects were categorized into Group I (single visit) and Group II (multiple visits).Clinical data was obtained and serum samples were collected both before and after 1 week of treatment completion. Inclusion criteria were those patients (a) over 18 years of age, (b) without any disease of inflammatory etiology, and (c) who had not previously received endodontic treatment or any related therapeutic treatment. Exclusion criteria were those (a) without a complete clinical history, (b) with greater than one indicated tooth, (c) who did not complete their treatment, and (d) with any periodontal disease. Chi-square and Student’s t -test were applied. Results: It was found that in single-sitting root canal treatment, there was a statistically significant reduction in these inflammatory biomarkers, although no difference in clinical efficacy was observed. Conclusion: Single-visit root canal treatment is a better option for treatment of pulpitis compared to multiple-sitting treatment.

The present work introduces the clinical case report of a 32-year-old male patient who sought the Department of Conservative Dentistry and Endodontics in Bangalore Institute of Dental Sciences, Bangalore with complaint of pain in the second upper left premolar. At the clinical examination, the tooth presented caries in the distal region, sensitivity to cold water and slight symptomatology to percussion. Radiographically the tooth presented a deep carious with pulp envelopment and thickening of the periodontal ligament in the apical region. During the opening of endodontic access a perforation occurred in the mesial region due to the incorrect direction of the drill. The perforation site was gently dried with hemostatic agent and then GIC was placed condensing along the perforation walls. Once this was done, root canal treatment was continued and the root canal was obturated to assess the attitude and practice of dental professionals towards using of advance radiographic technique.

An unusual case of an impacted right maxillary third molar that was accidentally displaced into the maxillary sinus during exodontia was surgically retrieved almost 2 months later is described. The tooth was removed under Local anesthesia, after maxillary sinus exposure through Caldwell-Luc approach. Postoperative recovery was uneventful. A month after the retrieval surgery, the maxillary sinus was fully healed and the patient did not present with any complaint.