In order to reveal the effect of vibration solidification on microstructure and properties of gray cast iron in lost foam casting, Y-shaped HT100 gray cast iron was prepared by vibration lost foam casting, and the effect of amplitude on the microstructure and properties of gray cast iron was studied. The results showed that, with the increase in amplitude, the short and thin A-type flake graphite increases, and the austenite structure transforms from columnar to cellular. The hardness, tensile strength, and elongation of gray cast iron first increase and then decrease with the increase in amplitude. The appropriate amplitude in the process of Y-shaped HT100 gray cast iron by lost foam casting is 2 mm, while the tensile strength and elongation of gray cast iron are the highest, with the values of 147.51 MPa and 1.17%, respectively. The change of mechanical properties of gray cast iron is mainly determined by the morphology and distribution of austenite in gray cast iron and A-type flake graphite.