Ada setengah pasien post stroke mengalami gangguan fungsi kognitif. Diabetes mellitus merupakan salah satu factor risiko stroke sekaligus factor risiko terjadinya gangguan fungsi kognitif. Tujuan penelitian adalah mengukur pengaruh diabetes mellitus terhadap gangguan fungsi kognitif post stroke iskemik. Penelitian ini menggunakan metode cross sectional. Data diambil dengan melakukan pengukuran fungsi kognitif pasien post stroke iskemik menggunakan instrument MoCA-INA dan CDT, data sekunder diambil dari Stroke Registry di RumahSakit Bethesda Yogyakarta pada tahun 2010-2017. Data dianalisis dengan chi-square test untuk analisis bivariat, serta regresi logistic untuk analisis multivariat. Dari 110 subjek penelitian terdapat pasien dengan gangguan fungsi kognitif (MoCA-INA < 26 dan CDT > 1) sebanyak 75 (68.2%) pasien, dan fungsi kognitif baik (MoCA-INA >= 26 dan CDT = 1) sebanyak 35 (31.8%) pasien. Analisis bivariat menunjukkan bahwa diabetes mellitus tidak berhubungan dengan gangguan fungsi kognitif post stroke iskemik (OR: 1.506, 95% CI: 0.654-3.466, p: 0.334). Analisis multivariate dengan regresi logistik didapatkan usia, onset, serangan stroke berulang, lesi temporal dan parietal sebagai faktor yang paling berpengaruh terhadap terjadinya gangguan fungsi kognitif post stroke iskemik. Simpulan penelitian ini adalah diabetes mellitus tidak mempengaruhi terjadinya gangguan fungsi kognitif post stroke iskemik.

AbstrakAda setengah pasien post stroke mengalami factor risiko stroke sekaligus factor pengaruh diabetes mellitus terhadap metode cross sectional. Data diambil menggunakan instrument MoCA-INA dan CDT, data sekunder Yogyakarta pada tahun 2010-2017. Data dianalisis untuk analisis multivariat. Dari 110 subjek dan CDT > 1) sebanyak 75 (68.2%) pasien, dan fungsi (31.8%) pasien. Analisis bivariat menunjukkan kognitif post stroke iskemik (OR: 1.506, 95% CI: 0.654 didapatkan usia, onset, serangan stroke berulang, lesi temporal dan parietal sebagai terhadap terjadinya gangguan fungsi kognitif post stroke iskemik. mempengaruhi terjadinya gangguan fun Kata kunci: stroke iskemik, gangguanfungsikognitif post stroke iskemik, diabetes mellitus Abstract There are half of post stroke patients experience cognitive impairment. Diabetes mellitus is one of the risk factors for stroke as well as risk factors for cognitive of diabetes mellitus on post-stroke isc Data were taken by measuring cognitive function of ischemic post stroke patients using MoCA instruments, secondary data were taken from Stroke Registry at Bethesda H were analyzed by chi-square test for bivariate analysis, as well as logistic regression for multivariate analysis. Of the 110 subjects there were patients with cognitive impairment (MoCA good cognitive function (MoCA-INA> 26 and CDT = 1) of 35 (31.8% ) patients. Bivariate analysis showed that diabetes mellitus was not associated with post 0.334). Multivariate analysis with logistic regression obtained age, onset, recurrent stroke, temporal and parietallesions as the most influential factor on the occurrence of cognitive post stroke ischemic function disorder. The conclusion of this study is diabetes mellitus does not affect the occurrence of cognitive impaired post stroke ischemic function.

Background: Paracetamol poisoning due to the use of paracetamol overdose is the most prevalent case of poisoning. Toxic metabolites from paracetamol cause glutathione depletion and lead to hepatic cell death. Curcumin, a polyphenol substrat in Curcuma longa, has been known to ameliorate the toxic effects of paracetamol. The mechanisms have been known are curcumin as antioxidant, anti-inflammatory, and anti-apoptotic. The curcumin protection mechanism against paracetamol poisoning will be discussed.Methods: The journal’s search for the protective effects of curcumin on paracetamol toxicity is derived from PubMed database using keyword curcumin and acetaminophen. Research on experimental animals is as the limits of the study subjects of the journal search.Result: From a search in PubMed database, there are 15 journal titles discussing the effects of curcumin protection against paracetamol toxicity, and 11 journals selected that correspond to the research topic. Of the 11 journals selected, concluded that curcumin was found to prevent worsening of paracetamol toxicity by increasing antioxidant activity and decreasing inflammation and apoptotic.Conclusion: Curcumin has the potential benefit to be used as a medical therapeutic for the prevention and treatment of paracetamol toxicity.