Appendicitis is a very rare clinical entity in neonates. Preterm and male neonates are commonly affected. It is often seen in association with surgical conditions like Hirschsprung's disease and necrotizing enterocolitis. Non-specific clinical features result in delay in the diagnosis and predisposes to perforation. The risk of perforation is very high (85%) in neonatal appendicitis. Management includes pre-operative stabilization, appendicectomy and peritoneal drainage in cases of perforation with peritonitis. Prognosis is uniformly poor with mortality rate as high as 70%. Herewith reporting a neonate with multiple perforations who was successfully managed.

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Dextropropoxyphene poisoning is an uncommon accidental poisoning in children. Presentation is similar to narcotic over dosage or poisoning. Convulsions, conduction disturbances, arrhythmias and hypoglycemia are common. Naloxone is the antidote. As it is uncommon and not documented in children in Indian literature we are reporting this case.