The first kinetically controlled,
highly trans-selective (>98%) olefin cross-metathesis
reaction is demonstrated
using Ru-based catalysts. Reactions with either trans or cis olefins afford products with highly trans or cis stereochemistry, respectively.
This E-selective olefin cross-metathesis is shown
to occur between two trans olefins and between a trans olefin and a terminal olefin. Additionally, new stereoretentive
catalysts have been synthesized for improved reactivity.
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