More than half a century, the scientific community is trying to understand the mechanisms and conditions of pollution dispersion within urban areas. Thereat, special attention has been focused on specific areas, such as a street canyon, in which harmful concentrations higher than allowed are more likely registered. However, there is still a controversy about the conditions of occurrence and impact of the individual air pollution components due to fluctuations of key contributions. Given that OSPM model is a well-known semi-empirical model specializing in the assessment of air quality within a street canyon, after its testing and validation, the results of subsequent simulations were used as a basis for planning a special experiment in order to implement 48 full factorial designs, where using the response surface methodology, as the final objective, an answer was precisely given on the impact and contribution of urban air pollution components. In addition to the main objective of this study, as a secondary, but not less important result defining emission factors for CO and NOx can be emphasized, which to date have not been determined for the fleet of the Republic of Serbia. [Projekat Ministarstva nauke Republike Srbije, br. TR 35041]