a b s t r a c tThe catalyst-free, regioselective synthesis of 4 0 -O-substituted pyridoxine derivatives under solventless conditions is described. The methodology relies on the highly regioselective formation of the orthopyridinone methide from pyridoxine and subsequent oxa-Michael addition of alcohol nucleophiles. This methodology provides good to excellent yields for primary and secondary alcohols and moderate yields for tertiary alcohols.
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