Introduction: Hyperglycaemia and abnormalities in simple carbohydrate, fat and protein metabolism are the characteristic feature of the metabolic disorder, Diabetes Mellitus. Diabetes mellitus treatment is achieved by modifications in diet, sleep pattern, regular physical activity followed by addition of anti-hyperglycemic drugs like metformin if HbA1C levels stays more than 7.0%.Materials and Methods The study period was from April 2019 – September 2019. The total duration of study was 24 weeks. Total 160 patients were screened; among them 100 participants were selected as per the inclusion criteria. Out of 100 patients, only 91 patients have completed the study. Conclusion To conclude DPP-4 inhibitor Teneligliptin 20mg OD exemplifies to be a pertinent add-on to Metformin 500mg BD to enhance the glycaemic control and could be an operative and reliable medication preference in T2DM through decent patient acceptability.

Introduction: Hyperglycaemia and abnormalities in simple carbohydrate, fat and protein metabolism are the characteristic feature of the metabolic disorder, Diabetes Mellitus. Diabetes mellitus treatment is achieved by modifications in diet, sleep pattern, regular physical activity followed by addition of anti-hyperglycemic drugs like metformin if HbA1C levels stays more than 7.0%.Materials and Methods The study period was from April 2019 – September 2019. The total duration of study was 24 weeks. Total 160 patients were screened; among them 100 participants were selected as per the inclusion criteria. Out of 100 patients, only 91 patients have completed the study. Conclusion To conclude DPP-4 inhibitor Teneligliptin 20mg OD exemplifies to be a pertinent add-on to Metformin 500mg BD to enhance the glycaemic control and could be an operative and reliable medication preference in T2DM through decent patient acceptability.

Cancer is not a modern disease but has been present since the very early dawn of life in both animals and humans”. Cancer is a disease that is caused due to alteration in the genetic configuration (mutation) that occurs due to either an inherent biological failure or an externally acquired factor leading to genomic instability and oncogenesis. The sudden upsurge in the incidence of cancer throughout the world in the last two decades has been attributed to the environmental and lifestyle changes which includes smoking, pollution, consumption of processed food etc…It is one among the prominent health problem responsible for morbidity and mortality. It is basically a cell proliferative disorder, initially specific to an organ and advances to invasion and metastasis. Chemotherapy with anticancer drugs remain the standard treatment modality. But those treatment drugs are associated with numerous serious side effects. On the other hand, phytomedicine is now attracting attention due to its potential anticancer properties. These medicines can be considered as an alternative form of therapy in cancer management due to their cost effectiveness, therapeutic efficacy and minimal side effects. Aesculus hippocastanum (AH)commonly known as European horse chestnut is found all over the world. The principal purpose of the study is to explore the anticancer property of ethanolic flower root out of Aesculus hippocastanum by performing the MTT assay (cytotoxic study) against human ovarian cell line. The study was evaluated by assessing the inhibition of percentage of cell viability and it showed minimum viability of cell (53.68 ± 0.8755 %) at the higher concentration of 200µl of Aesculus hippocastanum sample solution with Methotrexate as a standard comparison drug. This has proved the cytotoxic effect of Aesculus hippocastanum on PA1 human ovarian cancer cell line