My thesis work is dedicated to my husband, Yohan, who has been a constant source of support and encouragement during the challenges of graduate school. I am truly thankful to have you by my side, always.This work is also dedicated to my parents, in-laws, and grandparents, who have always loved me and stood as role models, teaching me to work hard for the things I aspire to achieve. I also dedicate this to my thesis advisor, academic advisor, preceptors, and to my friends and classmates who have supported me through this process. Ruby and Kevin, Michael, Lucy, Joscelyne and Gino, Kim and Henry, and Harold and Moni, thank you for being my best cheerleaders.