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Refugees arrive in the United States with medical and non-medical needs, many of which require collaborative support from multiple stakeholders. The Philadelphia Refugee Health Collaborative (PRHC) was developed through partnerships between resettlement agencies and health clinics to create an equitable and sustainable system to address these needs and improve resettlement success. By providing access to high-quality, community-centered health care, PRHC has successfully decreased the time to initial health screenings, connected refugees to a patient-centered medical home, and addressed complex medical needs of refugees, while improving the knowledge and capabilities of health care providers and community partners. These achievements have made the PRHC a model for providing continuing health care to newly arrived refugees, with a particular focus on those facing complex medical and social challenges.