Systemic infections with Nocardia species continue to be a serious threat to immunosuppressed hosts. Diagnosis of these infections can be difficult despite their known tendency for cerebral and subcutaneous involvement. We describe a patient who presented with nonspecific constitutional symptoms and was found to have subcutaneous and cerebral abscesses due to Nocardia farcinica. In addition, a blood culture yielded the organism. The patient responded remarkably to oral therapy; resolution of the cerebral disease was observed on serial magnetic resonance images. We discuss the important clinical features on N. farcinica infection, the rarity of positive blood cultures, and the importance of susceptibility testing of Nocardia species in selecting drug therapy.

An Optical Testing System (OTS) has been developed to measure the figure and radius of curvature of Next Generation Space Telescope (NGST) developmental mirrors in a vacuum, cryogenic environment using the X-Ray Calibration Facility (XRCF) at Marshall Space Flight Center (MSFC). The OTS consists of a WaveScope Shack-Hartmann sensor from Adaptive Optics Associates as the main instrument and a Leica Disto Pro distance measurement instrument. Testing is done at the center of curvature of the test mirror and at a wavelength of 632.8 nm. The error in the figure measurement is ≤λ/13 peak-to-valley (PV). The error in radius of curvature is less than 5 mm. The OTS has been used to test the Subscale Beryllium Mirror Demonstrator (SBMD), a 0.532 m diameter spherical mirror with a radius of curvature of 20 m. SBMD characterization consisted of three separate cryogenic tests at or near 35 K. The first two determined the cryogenic changes in the mirror surface and their repeatability. The last followed cryo-figuring of the mirror. This paper will describe the results of these tests. Figure results will include full aperture results as well as an analysis of the mid-spatial frequency error results. The results indicate that the SBMD performed well in these tests with respect to the requirements of λ/4 PV (full aperture), λ/10 PV (mid-spatial, 1-10 cm), and ±0.1 m for radius of curvature after cryo-figuring.

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