Graphical AbstractDiet-induced obese (DIO) C57BL/6 mice were treated for 14 days with VU0409106, a negative allosteric modulator of mGluR5. Food intake, body weight, inflammatory/hormonal levels, and behavioral tests were performed. Our data suggest reduction of feeding, body weight, and adipose tissue inflammation in DIO mice after chronic treatment with VU0409106.

Obesity represents a global health problem and is characterized by metabolic dysfunctions and a low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as atherosclerosis, diabetes and insulin resistance. Here we tested the hypothesis that the genetic deletion of metabotropic glutamate receptor 5 (mGluR5) may rescue metabolic and inflammatory features present in BACHD mice, a mouse model of Huntington’s disease (HD) with an obese phenotype. For that, we crossed BACHD and mGluR5 knockout mice (mGluR5−/−) in order to obtain the following groups: Wild type (WT), mGluR5−/−, BACHD and BACHD/mGluR5−/− (double mutant mice). Our results showed that the double mutant mice present decreased body weight as compared to BACHD mice in all tested ages and reduced visceral adiposity as compared to BACHD at 6 months of age. Additionally, 12-month-old double mutant mice present increased adipose tissue levels of adiponectin, decreased leptin levels, and increased IL-10/TNF ratio as compared to BACHD mice. Taken together, our preliminary data propose that the absence of mGluR5 reduce weight gain and visceral adiposity in BACHD mice, along with a decrease in the inflammatory state in the visceral adipose tissue (VAT), which may indicate that mGluR5 may play a role in adiposity modulation.

Neste artigo, os casos de censura à peça O Evangelho Segundo Jesus, Rainha do Céu, que retrata Jesus Cristo na pele da atriz transexual Renata Carvalho, são utilizados como o arcabouço ilustrativo para as discussões acerca da virada conservadora brasileira. O trabalho apresenta como objetivo principal traçar reflexões teóricas que relacionam o contexto do país ao cultural backlash, bem como discutir as noções de pânico moral e de liberdade de expressão. O percurso metodológico abrange revisão bibliográfica, análise documental de processos de caráter censório e estudo da repercussão dos casos na mídia a partir de um levantamento não sistemático de materiais jornalísticos. Como resultados, compreendemos que os gestos censórios, além de impedir o debate público sobre diversidade e impor atitudes autoritárias ao tentar coibir a arte, atuam também inviabilizando identidades e sujeitos que são violentamente estereotipados.