The emergence of pathogens is conferring resistance to last-resort therapies such as tigecycline, colistin, and carbapenems, limiting the therapeutic options, and raising concerns about the emergence of new “superbugs.” This study reports the first incident of a blaNDM–5 and tet(X4) co-harboring Escherichia coli with resistance to carbapenem and tigecycline recovered as the causative agent of a urinary tract infection in a 94-year-old patient. The E. coli strain ECCL209 carries multiple resistance genes [i.e., blaTEM–1B, blaNDM–5, blaCMY–2, aadA22, florR, erm(B), mph(A), erm(42), lnuG, qnrS1, and sul2] and exhibits resistance to almost all clinically used antibiotics. MLST analysis found that the strain belongs to ST648, considered a worldwide high-risk pandemic clone. Moreover, multiple plasmid incompatibility types were detected, i.e., IncHI1A, IncHI1B, IncFII, IncFIA, IncFIB, IncQ1, Col, and IncX4. Genetic analysis revealed that blaNDM–5 and tet(X4) genes were localized on two hybrid plasmids with multiple replicons. Continuous monitoring studies are suggested to quantify the antimicrobial resistance and assess the dissemination of such superbugs into a human healthcare setting.

Perencanaan arsitektur enterprise Sistem Informasi Dinas Tenaga Kerja, Sosial, dan Transmigrasi (Disnakersostrans) Kabupaten Purwakarta dirancang dengan menggunakan kerangka kerja The Open Group Architecture Framework (TOGAF) dengan metode Architecture Development Method (ADM). Penggunaan kerangka kerja TOGAF ADM digunakan sebagai acuan dalam merencanakan suatu arsitektur enterprise sistem informasi sehingga dapat dibangun suatu sistem informasi dan teknologi informasi yang saling terintegrasi dan selaras dengan kebutuhan aktivitas bisnis organisasi khususnya dalam pelayanan terhadap masyarakat. Pengumpulan data dilakukan dengan cara wawancara dan melakukan pengamatan langsung terhadap organisasi. Alat bantu analisis yang digunakan yaitu metode Unified Modelling Language (UML) dan metode Value Chain. Perencanaan arsitektur enterprise ini bertujuan untuk membangun sistem informasi dan teknologi informasi yang selaras dengan proses bisnis yang ada di Disnakersostrans Kabupaten Purwakarta. Hasil dari penelitian ini berupa blue print arsitektur bisnis, arsitektur data, arsitektur aplikasi yang menghasilkan lima aplikasi lama yaitu IPK, SIMPKH, SIMDA, SISKOTKLN dan TKA online dan dua puluh tiga aplikasi baru. Serta menghasilkan arsitektur teknologi berupa arsitektur jaringan sebagai acuan dalam pembangunan sistem lebih lanjut, sehingga dapat menunjang proses bisnis yang ada di Disnakersostrans Kabupaten Purwakarta.      Kata kunci: TOGAF, ADM, arsitektur enterprise, sistem informasi, blue print The enterprise information system architecture planning of Manpower, Social and Transmigration Office (Disnakersostrans) of Purwakarta is designed using The Open Group Architecture Framework (TOGAF) with Architecture Development Method (ADM). The TOGAF ADM framework is used as a reference in planning an enterprise information system architecture so that it can build an information system and information technology that is integrated and aligned with the needs of the organization's business activities especially in the service to the community. Data collection is done by interview and direct observation to the organization. Analytical tools used are Unified Modeling Language (UML) and Value Chain method. Enterprise architecture planning is aimed to build information systems and information technology in harmony with existing business processes in the Disnakersostrans Purwakarta. The results of this research are the blue print of business architecture, data architecture, application architecture that produces five old applications namely IPK, SIMPKH, SIMDA, SISKOTKLN and TKA online and twenty three new applications. As well as produce technology architecture in the form of network architecture as a reference in further development of the system, so it can support the existing business processes in the Office of Disnakersostrans Purwakarta.Keywords: TOGAF, ADM, enterprie architect, information system, blue print

Evaluasi sistem informasi diperlukan untuk mengetahui kesuksesan sistem yang diterapkan, termasuk pada sistem informasi akademik di Universitas Muhammadiyah Sukabumi. Penelitian ini menggabungkan model penerimaan teknologi informasi dan model kesuksesan sistem informasi yaitu UTAUT (Unified Theory of Acceptance Technology), D&M IS Success Model, dan HOT-Fit (Human Organization and Technology Fit) untuk menganalisa kesuksesan sistem informasi. Penggabungan model dipilih untuk meneliti pengaruh konstruk ke niat keperilakuan (behavioral intention) dan menghubungkan penggunaan dengan dampaknya. Disamping itu, ditambahkan pula variabel moderator yaitu gender untuk mengetahui hubungan faktor individu (human context) dengan niat keperilakuan. Model persamaan yang digunakan dalam penelitian ini adalah Structural Equation Model (SEM) menggunakan SPSS AMOS v.22. Variabel yang digunakan dalam model terintegrasi ini antara lain faktor manusia, faktor teknologi, faktor organisasi, niat keperilakuan, kepuasan pengguna, dan manfaat-manfaat bersih. Pengujian yang dilakukan meliputi pengujian reliabilitas, CFA, teknik Kolmogrov-Smirnov Goodness of Fit Test, hingga pengujian keseluruhan model.Kata kunci: UTAUT, D&M IS Success Model, HOT-Fit, SEM

 The rapid development of technology and with the disruptive technology make multimedia developers continuously innovate in making specific information products. Internet as a source of information can be used as a reference to seek various information such as information about custom clothing from around the world. In addition to sources from the internet, many available information about custom clothing for example in print. The use of both media is found a variety of problems that Internet users must search for one by one information and readers should find information custom clothing one by one following details and explanations. The problem is solved by creating a digital encyclopedia about custom clothing in digital form based on multimedia technology using mobile application with Android operating system. The method for multimedia software engineering uses Luther method with its stages of concept, design, collecting material, assembly, testing, and distribution. The end result of this research in the form of multimedia products encyclopedia custom clothing in the form of android applications. Product test results have been passed using functionality testing and all functions can run well and in accordance with the concept. From the results of the survey on beta test results obtained 83% which states that the application is feasible to use.

Capital markets have become increasingly important in driving a country’s economy. The capital markets could perform their role effectively if there is available information for investors. Along with the evolution of information technology, information dissemination by companies could be done more efficiently and promptly manner, for example using corporate websites. However, information dissemination through corporate websites (web disclosure) has not been fully utilized by companies, especially Indonesian companies. Therefore, this research analyzed the factors influencing web disclosure by manufacturing companies in Indonesia. The hypothesis testing was conducted with Partial Least Square Structural Equation Modeling on 54 Indonesian manufacturing companies listed on Indonesia Stock Exchange. The analysis found that company size and corporate governance mechanisms have a positive relationship, and leverage has a negative relationship with web disclosure. The results have also found no relationship between culture and profitability with web disclosure.