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A study was performed on the functional regulator, Frankel appliance (FR4) in order to test its efficiency in the treatment of patients with skeletal open-bite. Pretreatment and post-treatment cephalometric evaluation was done on 11 patients and 10 untreated patients with skeletal open-bite. The results showed that the FR4 appliance was mainly effective on changes in dentoalveolar structures and produced no significant skeletal changes. The degree of anterior open-bite was decreased significantly in the treatment group in comparison with the controls (p<0.01), due to vertical eruption of upper and lower incisors and retraction of maxillary incisors.