Objectives: To evaluate pattern and presentation of pyogenic granuloma in pregnant patients. Study Design: Descriptive study with non-probability purposive technique. Setting: Department of Oral & Maxillofacial Surgery Liaquat University hospital Hyderabad. Period: From February 2013 to January 2017. Material & Methods: A total number of fifty pregnant patients were included in the study and preliminary diagnosis of gingival pyogenic granuloma was made clinically. The clinical diagnosis was confirmed by excisional biopsy under local anesthesia (surgical procedure was done following consultation with primary care physician in second trimester or after parturition), and sent for histopathological examination. Removal of dental plaque performed before surgical therapy. Results: Most of the females involve were in age group of 21-30 (68%). Maxillary anterior region was most frequently involved followed by mandibular anterior region. The smallest size of lesion was 1.5mm and largest was 3cm. Conclusion: Pyogenic granuloma in pregnancy occur due to hormonal imbalance, however bacterial dental plaque, calculus and poor oral hygiene are also key factors in development.