In this work, Zn(II) phthalocyanine derivative (TTU-Pc) bearing 13-membered tetrathia macrocycles was synthesized, and the novel Zn(II) phthalocyanine derivative was fully characterized by elemental analysis and general spectroscopic methods such as MALDI-TOF mass, FT-IR, UV-vis and [Formula: see text]H-NMR. The synthesized phthalocyanine derivative has quite limited solubility in most of the common organic solvents. Fluorescence measurement was conducted for this Zn(II)phthalocyanine to estimate its fluorescence quantum yields. The singlet oxygen generation ability was also examined to investigate its photosensitizer properties. General trends were described for quantum yields of fluorescence, photodegradation and singlet oxygen quantum yields of this compound. The electrochemical properties of the molecule were investigated by cyclic voltammetry (CV) and square wave voltammetry (SWV). In addition, the lowest energy structure, the electronic structure and frontier molecular orbitals were calculated in DFT and the excitation spectrum was obtained by TDDFT calculations. We found that our computational and experimental results were in agreement.

Background/aim Most of the hospitalized patients are on a number of drugs for comorbidities and/or to prevent nosocomial infections. This necessitates a careful consideration of drug interactions not only to avoid possible toxicities but also to reach the highest efficiency with drug treatment. We aimed to investigate drug interactions related to systemic antibiotic use and compare three different databases to check for drug interactions while characterizing the main differences between medical and surgical departments. Materials and methods This point prevalence study covered data on 927 orders for patients hospitalized between June 3 and 10, 2018 in Ankara University Hospitals. Systemic antibiotic use and related drug interactions were documented using UptoDate, Drugs, and Medscape and comparisons between the departments of medical and surgical sciences were made. Results The number of orders, or the number of drugs or antibiotics per order were not different between the medical and surgical sciences departments. A total of 1335 antibiotic-related drug interactions of all levels were reported by one, two, or all three databases. UptoDate reported all common and major interactions. Pantoprazole was the most commonly prescribed drug and appeared in 63% of all orders. Among 75 different molecules, ceftriaxone and meropenem were the two most prescribed antibiotics by the surgical and medical departments, respectively. Conclusion A dramatic variance existed amongst antibiotics prescribed by different departments. This indicated the requirement for a centralized role of an infectious diseases specialist. Especially for the hospitalized patient, prophylactic coverage with at least one antibiotic brought about a number of drug interactions. A precise evaluation of orders in terms of drug interactions by a clinical pharmacist (currently none on duty) will reduce possible drug-related hazards.

Objective: Pharmacists have important roles in pharmaceutical care practices. In this study, it was aimed to investigate the potential benefits of the presence of a pharmacist in PHCs (Primary Health Care) in addition to other health care specialists in Ankara Kecioren Karargahtepe PHC and Ankara Ayas PHC.Material and Method: This study is a quasi-experimental type of study which includes a pre-test and a post-test. Pre-test was given to patients by two pharmacists, which was followed by a basic education on hypertension and its treatment. A post-test was done three months after the pre-test in order to assess the efficiency of the education.Result and Discussion: In total, 103 patients (70.9% female; mean age: 62.84 ± 10.44 years) were analysed before and after receiving counselling from two pharmacists. The results of pre-and post-tests were analyzed by Wilcoxon t-test using SPSS 23.0. As a result of the statistical analysis, the education provided by the pharmacists enhanced the mean patient scores significantly (T0 (pre-test) = 6 (5-7), T1 (post-test) = 8 (6-9); P ˂ 0.05). This study revealed the active role and the requirement of the presence of a pharmacist in addition to other health care providers in PHCs.

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Ülkemizde çok yeni olan klinik eczacılığa dair araştırmalar yapılmakta ve sağlık sistemi açısından önemli adımlar atılmaktadır. Şöyle ki; üniversitelerde klinik eczacılık yüksek lisans ve doktora programlarının açılmasının yanı sıra Sağlık Bakanlığı, eczacılıkta uzmanlık alanlarından biri olarak "klinik eczacılık" alanını belirlemiştir. Böylece hasta odaklı olarak nitelendirdiğimiz sağlık sisteminde; klinik eczacı, hekim ve hasta arasında önemli bir köprü görevi görmektedir. Bu çalışma ile klinik eczacıların 2006-2016 yılları arasında klinik eczacılık uygulamaları ile ilgili vakalar derlenerek, Türkiye'de yeni olan Klinik Eczacılık uzmanlık alanı ile birlikte sıkça gündeme gelen klinik eczacılığın öneminin ortaya konulması amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmamızda PubMed veri tabanına ''klinik eczacılık'' sözcüğü verilerek; hastalığa spesifik, eczacının rolünün ortaya konduğu, İngilizce ve tam metne ulaşılabilen makalelerin seçilmesine özen gösterilmiştir. B Bu ul lg gu ul la ar r: : Bu özellikte elde edilen 46 makalenin incelenmesi sonucunda; klinik eczacının aktif olarak rol aldığı 46 vakanın en fazla kalp-damar sistemi hastalıkları ile ilgili olduğu saptanmıştır. Araştırmalarda prospektif çalışmaların çok fazla olduğu, bunun yanında retrospektif ve randomize kontrollü çalışmalar olduğu; bunların bir kısmının gözlemsel, bir kısmının girişimsel olduğu belirlenmiştir. S So on nu uç ç: : İncelediğimiz çoğu makalede klinik eczacının, çalışma sonuçlarına olumlu etkisi olduğu saptanmıştır. Örneğin; yaşam kalitesinin yükseltilmesinde, ilaç tedavisinin optimizasyonunun sağlanmasında ve hasta uyuncunun artırılmasında klinik eczacının önemli rolü bulunmaktadır. Ayrıca klinik eczacı, hekim ile birlikte hasta için en uygun ilaç tedavisini etik ilkeler doğrultusunda sağlayacak bir sağlık meslek çalışanı olmalıdır. Ancak bu doğrultuda, klinik eczacının etik tutumları ile ilgili yayına ulaşılamamıştır.