Non-biological complex drugs have emerged as a new drug group in recent years. These complex drugs are medicinal products, not being a biological or chemical medicine, where the active substance is not a homomolecular structure, but consists of different structures that cannot be isolated and fully characterized by state of the art physicochemical analytical methods, not synthesized chemically, not biological and often complex with nanoparticle systems. Non-biological complex drugs include liposomes, glatiramoids, iron carbohydrate complexes, polymeric micelles and nanodrugs. These drugs differ from biological and chemical medicines in terms of preparation technology. The major problem that arises during the production of non-biological complex drugs is the inability to control the production process and therefore the differences between the series. As biosimilar products, similar products are obtained in every different production series. Physicochemical properties, such as size and size distribution, surface charge and composition of non-biological complex drugs are factors that effects interaction with biological systems and thus their biological activities. Although not derived from living sources, they have immunogenicity and molecular complexity like biological drugs. Minor changes in

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