Blended learning refers to the model of integration between face-to-face learning and online instruction. This model used in coronavirus disease 2019 (COVID-19) pandemic, essential for prevention and control the emerging infectious disease transmission, and enhanced achievement of expected learning outcomes among nursing students. This article aimed to present a blended instruction based on asynchronous and synchronous online learning with face-to-face approach in primary medical care course for nursing students in the new normal era. The instructional design based on the 5 components of the ADDIE model including 1) analysis, 2) designs, 3) development, 4) implementation, and 5) evaluation. The conceptual framework for evaluating blended learning outcomes including 1) learners’ satisfaction, 2) students’ engagement, and 3) course outcomes. It was found that the learners’ satisfaction on blended learning were at high level. Blended learning performs a pivotal role in supporting nursing students’ engagement. All nursing students gained higher scores than the pass criteria. This article determined on improving nursing education through blended learning and extended novel issues for further research and development.