SUMMARY A metacentric bisatellited microchromosome was detected in all metaphases from an amniotic culture performed because of maternal age. A wide-ranging survey of the literature failed to disclose any consistent anomaly associated with such a marker, but did reveal that the clinical picture of patients manifesting it could range from complete normality through mental retardation to a variety of deformities. The parents elected for termination, and the only deformity detected in the abortus was fixed talipes equinovarus. The implications of the finding of this marker chromosome on amniocentesis, believed to be reported for the first time here, are discussed particularly in the context ofgenetic counselling.

No abstract

No abstract

Summary: A single injection of hexoestrol, 45 mg., is effective in suppressing lactation. Given in this way hexoestrol causes a small rise in plasma factor IX levels, of shorter duration than that produced by a customary and equally effective oral course of stilboestroL With hexoestrol the plasma factor IX levels reverted to normal by the sixth day of the puerperium.

Placental localization was performed on 100 patients by two methods, the Doptone ultrasonic apparatus and radioactive carbon monoxide using the gamma camera. Confirmation of the exact site of the placenta was obtained by Caesarean section in 50 cases. Localization with the Doptone apparatus proved to be simple, inexpensive and accurate. It compared favourably with the radio-isotopic method, which exposed the patient to a small dose of radiation and required complex laboratory-based equipment.