Three asbestos‐free depth‐filters were compared with traditionally used asbestos‐containing depth‐filters for chemical integrity, physical integrity and pyrogen retention. With chemical and physical integrity only minor differences between the various filter types were seen. One asbestos‐free depth‐filter, based on charcoal, showed poor pyrogen‐retention; this might be due to a high flow rate used. Asbestos‐free depth‐filters based on kieselguhr or on a mixture of kaolin and alumina proved to be good alternatives; these filters have proved to be suitable for the removal of pyrogens from electrolyte‐ or carbohydrate‐containing infusion fluids.