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3,4-Diphenyl-2a,5a,6,7,8,8a,8b-heptahydro-furo[4,3,2-de]chromen-2-one (1) was prepared as part of a project aimed at the synthesis of polycyclic natural-product-like scaffolds. X-ray analysis of crystals grown from ethanol revealed an incommensurately modulated structure. Data include main and satellite reflections up to second order. The modulation vector was refined using the NADA program. The modulated character of the structure of the organic compound C(22)H(20)O(3) is interpreted in terms of the intermolecular C-H...O hydrogen bonds and close-contact approximation.

Bicyclic furopyranones containing the cis‐stilbene motif are described. The derivatives show antiproliferative activity in A549 and KB31 cells. The presence of the cis‐stilbene motif is critical for biological activity. The compounds induce cell cycle arrest at the G2/M transition.