Acute hind‐limb ischaemia was produced in anaesthetized, ventilated dogs. During ischaemia the femoral venous oxygen tension fell markedly and both oxygen extraction and consumption appeared to increase. Oxygen at 2 ATA produced a relatively small increase in oxygen availability to the ischaemic tissues; femoral venous oxygen tension rose by 20 mm. Hg but oxygen extraction and consumption remained elevated.

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Limb blood-flow (ml. per min.) pvco, (mm., Hg) 0, availability (ml. per min.) 0, extraction (per cent) OI consumption (ml. per min.) Excess lactate (mmol per litre) Pvo, (mm. Hg)