Lucknomycin is a new polyenic derivative antifungal agent obtained from a Streptomyces diastatochromogenes culture. The in vitro activity of the compound was tested against 403 strains of different Candida species of clinical origin by the Sabou-raud Agar dilution method. The mean geometrical value of the minimal inhibitory concentrations (MIC) for Candida albicans was 0.85 μg/ml, 6 times lower than the corresponding value of nystatin (5.29 μg/ml) and very close to that of amphotericin B (0.56 jUg/ml). Lucknomycin was also 4–10 times more active than nystatin on other Candida species, with an MIC similar to those obtained with amphotericin B.

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