In an effort to improve on our diagnostic yield from percutaneous transthoracic biopsy, we used 14-gauge cutting needles in 56 selected patients. These biopsies were pre- [9,[13][14][15][16][17][18].In an attempt to improve these previous results, we reintroduced the large cutting needle for the biopsy of carefully selected chest lesions. This report reviews our experience with 56 chest biopsies performed with a lange-bore cutting needle during the last 6 years. In 42 patients, results from their cutting-needle biopsies were compared with those from their aspiration biopsies. This study establishes the diagnostic advantages of lange-bone cutting-needle biopsies and shows their safety, when they are used according to specified methods in a select group of patients. From 1981From to mid-1987 Methods