Three patients with benign and malignant adenomyoepithelioma were included in this study. The imaging and histopathologic findings in these three patients are illustrated, and the treatment of patients with this unusual tumor is discussed.

Olsalazine (azodisalicylate) is a new drug in which two molecules of 5-aminosalicylic acid are linked by an azo bond. Its role in the treatment of mildly active, distal ulcerative colitis was investigated. Sixty patients were randomly allocated to receive olsalazine 1 g or a placebo as a retention enema nightly for two weeks.

SUMMARY One hundred and sixty four patients with ulcerative colitis in remission were entered into a double blind, double dummy trial comparing olsalazine 500 mg bd and sulphasalazine 1 g bd. Clinical examination, sigmoidoscopy and rectal biopsy were performed at 0, three, and six months. Sixteen of 82 (19 5%) patients relapsed on olsalazine and 10/82 (12 2%) relapsed on sulphasalazine. The difference was not statistically significant (p=0-1632). Adverse events were minor and were similar in both groups. No haematological or biochemical abnormalities were detected. Thus, olsalazine is as effective as sulphasalazine for preventing a relapse of ulcerative colitis.Sulphasalazine (SASP) has been the mainstay of maintenance therapy for ulcerative colitis (UC) since its discovery in 1940.'-`Increasing awareness of the side effects of the sulphapyridine (SP) moiety,4 coupled with the discovery that 5-ASA is the active ingredient for UC,5 has resulted in extensive investigation into alternative ways of delivering 5-ASA to the colon. Olsalazine (Dipentum®) is a drug in which the SP molecule is replaced by another molecule of 5-ASA, the drug thereby releasing two molecules of 5-ASA upon azo reduction in the colon.6 Olsalazine is of proven value in patients intolerant of SASP,7`and is also effective when given orally to patients with a mild relapse of UC.9 A recent Swedish study has shown it to be superior to placebo in maintaining UC in remission over a six month period."The aim of this study was to compare olsalazine with sulphasalazine in patients with UC in remission, over a six month period.

No abstract

Two cases of combined goblet cell carcinoid and mucinous cystadenoma occurring in the appendix are reported. The histogenesis of the goblet cell carcinoid remains one of its most controversial aspects and the occurrence of both of these relatively uncommon tumours in the same organ may lend support to the unitary stem cell hypothesis on the origin of this tumour. Alternatively, this occurrence may represent an example ofthe adenoma/ carcinoma sequence. ( Clin Pathol 1995;48:869-870) Keywords: Goblet cell carcinoid, mucinous cystadenoma, appendix, histogenesis.Goblet cell carcinoid is an uncommon tumour of the appendix showing features of both a carcinoid and an adenocarcinoma.12 The mucinous cystadenoma is an epithelial neoplasm which represents the appendiceal counterpart of the more common colonic adenoma.34 In this report we wish to describe the existence of both tumours within the appendices of two patients. This is an unusual occurrence which raises the possibility of a related histogenesis. Case reports CASE ONE An adherent pelvic appendix was resected with difficulty from a 54 year old woman admitted for an interval appendicectomy, two months after an attack of appendicitis. The appendix measured 60 x 15 mm and was irregular, distorted and showed serosal fibrosis. On sectioning, the tip of the appendix was distended and a mucus containing diverticulum penetrating the muscular wall of the appendix was identified. CASE TWOA 64 year old woman was admitted with a four month history of a dull ache in the right iliac fossa which had become increasingly severe over the last week. Eight months earlier, the patient had been admitted with a similar episode of pain which had been treated conservatively. The patient underwent appendiectomy. The resected appendix measured 65 x 12 mm and had a distended, fibrotic tip which contained two small diverticulae on sectioning.Pathology Both appendices were of very similar appearance on histology. The diverticulae noted were produced on the basis of a mucinous cystadenoma. The lumen was focally dilatated and lined by mucus secreting columnar epithelium. The epithelium was mainly flattened with focal papillary areas. Cellular crowding with pseudo-stratification and mild to moderate atypia were noted on cytology (fig 1)